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dd fw microsoftPossible change in the role of Wnt pathway in endometrial cancer. Wnt pathway activation has been suggested to be a critical step for endometrial carcinogenesis, but the role of Wnt pathway in endometrial cancer has been controversial. This review aimed to clarify the roles of Wnt pathway in endometrial cancer through recent evidences. This review was performed by searching Pubmed with keyword "Wnt" in combination with "endometrial cancer" for papers written until December 2011. Many studies found that Wnt pathway was involved in the development and progression of endometrial cancer. Studies also demonstrated that Wnt pathway was activated in the endometrium in the progesterone non-dependent state, and was inhibited by progesterone. Wnt pathway was also implicated in the tumor growth and metastasis of endometrial cancer by the production of stromal-derived factor 1 and its receptor CXCR4. Recent studies also showed the importance of Wnt pathway in the apoptosis of endometrial cancer cells. Wnt signaling pathway plays a role in the pathogenesis and progression of endometrial cancer.